117 research outputs found
Controlled deflection of cold atomic clouds and of Bose-Einstein condensates
We present a detailed, realistic proposal and analysis of the implementation
of a cold atom deflector using time-dependent far off-resonance optical guides.
An analytical model and numerical simulations are used to illustrate its
characteristics when applied to both non-degenerate atomic ensembles and to
Bose-Einstein condensates. Using for all relevant parameters values that are
achieved with present technology, we show that it is possible to deflect almost
entirely an ensemble of Rb atoms falling in the gravity field. We
discuss the limits of this proposal, and illustrate its robustness against
non-adiabatic transitions
Clusters of Exceptional Points for a Laser Control of Selective Vibrational Transfer
When a molecule is exposed to a laser field, all field-free vibrational
states become resonances, with complex quasi energies calculated using Floquet
theory. There are many ways to produce the coalescences of pairs of such quasi
energies, with appropriate wavelength-intensity choices which define
Exceptional Points (EP) in the laser parameter plane. We dress for the
molecular ion H an exhaustive map of these exceptional points which
appear in clusters. Such clusters can be used to define several vibrational
transfer scenarios implying more than a single exceptional point, exchanging
single or multiple vibrational quanta. The ultimate goal is molecular
vibrational cooling by transferring an initial (thermal, for instance)
population on a final (ground, for instance) single vibrational state. When a
molecule is exposed to a laser field, all field-free vibrational states become
resonances, with complex quasi energies calculated using Floquet theory. There
are many ways to produce the coalescences of pairs of such quasi energies, with
appropriate wavelength-intensity choices which define Exceptional Points (EP)
in the laser parameter plane. We dress for the molecular ion H an
exhaustive map of these exceptional points which appear in clusters. Such
clusters can be used to define several vibrational transfer scenarios implying
more than a single exceptional point, exchanging single or multiple vibrational
quanta. The ultimate goal is molecular vibrational cooling by transferring an
initial (thermal, for instance) population on a final (ground, for instance)
single vibrational state.Comment: 16 pages, 7 figures, 1 tabl
Bose-Einstein condensation in dark power-law laser traps
We investigate theoretically an original route to achieve Bose-Einstein
condensation using dark power-law laser traps. We propose to create such traps
with two crossing blue-detuned Laguerre-Gaussian optical beams. Controlling
their azimuthal order allows for the exploration of a multitude of
power-law trapping situations in one, two and three dimensions, ranging from
the usual harmonic trap to an almost square-well potential, in which a
quasi-homogeneous Bose gas can be formed. The usual cigar-shaped and
disk-shaped Bose-Einstein condensates obtained in a 1D or 2D harmonic trap take
the generic form of a "finger" or of a "hockey puck" in such Laguerre-Gaussian
traps. In addition, for a fixed atom number, higher transition temperatures are
obtained in such configurations when compared with a harmonic trap of same
volume. This effect, which results in a substantial acceleration of the
condensation dynamics, requires a better but still reasonable focusing of the
Laguerre-Gaussian beams
The Effect of the Stationary Phase on Resolution in the HPLC-Based Separation of Racemic Mixtures Using Vancomycin as a Chiral Selector: A Case Study with Profen Nonsteroidal Anti-Inflammatory Drugs
\ua9 2023 by the authors.Chiral resolution is a technique of choice, making it possible to obtain asymmetric and enantiomerically pure compounds from a racemic mixture. This study investigated the behavior of vancomycin when used as a chiral additive in high-performance liquid chromatography (HPLC) to separate enantiomers of nonsteroidal anti-inflammatory drugs (NSAIDs), including ketoprofen, ibuprofen, flurbiprofen, and naproxen enantiomeric impurities. We compared two achiral stationary phases (C18 and NH2) to assess the impact of mobile phase composition and stationary phase on the vancomycin retention time in the racemic resolution of drug enantiomers. Our results demonstrated the successful enantioseparation of all drugs using vancomycin in the mobile phase (phosphate buffer 0.05 M/2-propanol, 50/50) with an NH2 column. This enhanced separation on the NH2 column resulted from the chromatography system’s efficiency and vancomycin dimers’ stereoselective interaction on the NH2 surface. This study underscores the importance of stationary phase selection in the chiral resolution of NSAIDs with vancomycin as a chiral additive. It offers valuable insights for future research and development of NSAID chiral separation methods, highlighting potential vancomycin applications in this context
Inhibition of Fungi and Gram-Negative Bacteria by Bacteriocin BacTN635 Produced by Lactobacillus plantarum sp. TN635
The aim of this study was to evaluate 54 lactic acid bacteria (LAB) strains isolated from meat, fermented vegetables and dairy products for their capacity to produce antimicrobial activities against several bacteria and fungi. The strain designed TN635 has been selected for advanced studies. The supernatant culture of this strain inhibits the growth of all tested pathogenic including the four Gram-negative bacteria (Salmonella enterica ATCC43972, Pseudomonas aeruginosa ATCC 49189, Hafnia sp. and Serratia sp.) and the pathogenic fungus Candida tropicalis R2 CIP203. Based on the nucleotide sequence of the 16S rRNA gene of the strain TN635 (1,540 pb accession no FN252881) and the phylogenetic analysis, we propose the assignment of our new isolate bacterium as Lactobacillus plantarum sp. TN635 strain. Its antimicrobial compound was determined as a proteinaceous substance, stable to heat and to treatment with surfactants and organic solvents. Highest antimicrobial activity was found between pH 3 and 11 with an optimum at pH = 7. The BacTN635 was purified to homogeneity by a four-step protocol involving ammonium sulfate precipitation, centrifugal microconcentrators with a 10-kDa membrane cutoff, gel filtration Sephadex G-25, and C18 reverse-phase HPLC. SDS-PAGE analysis of the purified BacTN635, revealed a single band with an estimated molecular mass of approximately 4 kDa. The maximum bacteriocin production (5,000 AU/ml) was recorded after a 16-h incubation in Man, Rogosa, and Sharpe (MRS) medium at 30 °C. The mode of action of the partial purified BacTN635 was identified as bactericidal against Listeria ivanovii BUG 496 and as fungistatic against C. tropicalis R2 CIP203
The Making of the NEAM Tsunami Hazard Model 2018 (NEAMTHM18)
The NEAM Tsunami Hazard Model 2018 (NEAMTHM18) is a probabilistic hazard model for tsunamis generated by earthquakes. It covers the coastlines of the North-eastern Atlantic, the Mediterranean, and connected seas (NEAM). NEAMTHM18 was designed as a three-phase project. The first two phases were dedicated to the model development and hazard calculations, following a formalized decision-making process based on a multiple-expert protocol. The third phase was dedicated to documentation and dissemination. The hazard assessment workflow was structured in Steps and Levels. There are four Steps: Step-1) probabilistic earthquake model; Step-2) tsunami generation and modeling in deep water; Step-3) shoaling and inundation; Step-4) hazard aggregation and uncertainty quantification. Each Step includes a different number of Levels. Level-0 always describes the input data; the other Levels describe the intermediate results needed to proceed from one Step to another. Alternative datasets and models were considered in the implementation. The epistemic hazard uncertainty was quantified through an ensemble modeling technique accounting for alternative models’ weights and yielding a distribution of hazard curves represented by the mean and various percentiles. Hazard curves were calculated at 2,343 Points of Interest (POI) distributed at an average spacing of ∼20 km. Precalculated probability maps for five maximum inundation heights (MIH) and hazard intensity maps for five average return periods (ARP) were produced from hazard curves. In the entire NEAM Region, MIHs of several meters are rare but not impossible. Considering a 2% probability of exceedance in 50 years (ARP≈2,475 years), the POIs with MIH >5 m are fewer than 1% and are all in the Mediterranean on Libya, Egypt, Cyprus, and Greece coasts. In the North-East Atlantic, POIs with MIH >3 m are on the coasts of Mauritania and Gulf of Cadiz. Overall, 30% of the POIs have MIH >1 m. NEAMTHM18 results and documentation are available through the TSUMAPS-NEAM project website (http://www.tsumaps-neam.eu/), featuring an interactive web mapper. Although the NEAMTHM18 cannot substitute in-depth analyses at local scales, it represents the first action to start local and more detailed hazard and risk assessments and contributes to designing evacuation maps for tsunami early warning.publishedVersio
Guiding principles for the development and application of solid-phase phosphorus adsorbents for freshwater ecosystems
While a diverse array of phosphorus (P)-adsorbent materials is currently available for application to freshwater aquatic systems, selection of the most appropriate P-adsorbents remains problematic. In particular, there has to be a close correspondence between attributes of the P-adsorbent, its field performance, and the management goals for treatment. These management goals may vary from a rapid reduction in dissolved P to address seasonal enrichments from internal loading, targeting external fluxes due to anthropogenic sources, or long term inactivation of internal P inventories contained within bottom sediments. It also remains a challenge to develop new methods and materials that are ecologically benign and cost-effective. We draw on evidence in the literature and the authors’ personal experiences in the field, to summarise the attributes of a range of P-adsorbent materials. We offer 'guiding principles' to support practical use of existing materials and outline key development needs for new materials
- …